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KMID : 0379119850130010011
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Korean Journal of Mycology
1985 Volume.13 No. 1 p.11 ~ p.21
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Studies on Constituents of the Higher Fungi of Korea (38)
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Choi Eung-Chil
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Abstract
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Antitumor components were obtained from the cultured mycelia of Pleurotus pulmonarius by ethanol precipitation. The protein-bound polysaccharide was subjected to DEAE-Sephadex column chromatography and Sephadex G-200 gel filtration. The antitumor fraction C₁ was isolated. The inhibition ratio of fraction C₁ was 81.8% in the doses of 10 ㎎/㎏/day for 10 days. The antitumor fraction C₁ consisted of a polysaccharide and a protein. The protein-moiety was composed of 14 amino acids. From the peritoneal cell populations in the mice given antitumor fraction C₁, the injection of the fraction caused the influx of peritoneal macrophages at two days when compared with those of soluble starch. This was named pulmonaran after its species name.
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